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Seiji Tamura Selected Research

indeloxazine

6/2015AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in rat models of nociceptive pain.
6/2014Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline.
4/2014AS1069562, the (+)-isomer of indeloxazine, but not duloxetine has a curative-like analgesic effect in a rat model of streptozotocin-induced diabetic neuropathy.
3/2014AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover.

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Seiji Tamura Research Topics

Disease

6Pain (Aches)
06/2015 - 09/2007
4Hyperalgesia
06/2014 - 09/2007
2Neuralgia (Stump Neuralgia)
06/2015 - 03/2014
2Cerebrovascular Disorders (Cerebrovascular Occlusion)
04/2014 - 03/2014
1Arthritis (Polyarthritis)
06/2015
1Nociceptive Pain
06/2015
1Hypersensitivity (Allergy)
06/2014
1Body Weight (Weight, Body)
04/2014
1Diabetic Neuropathies (Diabetic Neuropathy)
04/2014
1Bone Resorption
07/2008
1Neoplasm Metastasis (Metastasis)
07/2008
1Infarction (Infarctions)
01/2008
1Stroke (Strokes)
01/2008
1Chronic Pain
09/2007
1Nervous System Diseases (Neurological Disorders)
10/2005

Drug/Important Bio-Agent (IBA)

6Analgesics (Analgesic Drugs)IBA
06/2015 - 09/2007
4Norepinephrine (Noradrenaline)FDA LinkGeneric
06/2015 - 03/2014
4indeloxazineIBA
06/2015 - 03/2014
4Serotonin (5 Hydroxytryptamine)IBA
06/2015 - 03/2014
4Duloxetine Hydrochloride (Cymbalta)FDA Link
06/2015 - 03/2014
2Antidepressive Agents (Antidepressants)IBA
06/2014 - 03/2014
2Amitriptyline (Elavil)FDA LinkGeneric
06/2014 - 03/2014
2Streptozocin (Streptozotocin)FDA Link
04/2014 - 09/2007
2Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA
01/2008 - 09/2007
1BradykininIBA
06/2015
1Dinoprostone (PGE2)FDA Link
06/2014
1resiniferatoxinIBA
06/2014
15-HT3 Serotonin Receptors (5 HT3 Receptor)IBA
06/2014
1ProstaglandinsIBA
06/2014
15-HT1A Serotonin ReceptorIBA
06/2014
1Glucose (Dextrose)FDA LinkGeneric
04/2014
1Serotonin and Noradrenaline Reuptake InhibitorsIBA
04/2014
1morpholineIBA
03/2014
1AcidsIBA
07/2008
1Diphosphonates (Bisphosphonates)IBA
07/2008
1Neuroprotective AgentsIBA
01/2008
1N- cyclohexyl- 6- (((2- methoxyethyl)(methyl)amino)methyl)- N- methylthiazolo(3,2- a)benzimidazole- 2- carboxamideIBA
01/2008
1Freund's AdjuvantIBA
09/2007
1(R)- N- cycloheptyl- 6- ((((tetrahydro- 2- furyl)methyl)amino)methyl)thieno(2,3- d)pyrimidin- 4- ylamineIBA
09/2007
1metabotropic glutamate receptor type 1IBA
10/2005

Therapy/Procedure

1Spinal Injections
06/2014
1Analgesia
06/2014